Health researchers warned that Aspirin Can Cause Internal Bleeding ,so patients of Gastrointestinal Bleedings , and and suffering in Dengue Fever may be avoided to use it .Taking aspirin to protect against having a stroke or a heart attack where there is no visible evidence of heart problems should be avoided, according to new medical research published by the DTB (Drugs and Therapeutics Bulletin). Aspirin, it says, is capable of inducing significant internal, gastrointestinal bleeding, and there is no concrete link between it and heart disease death prevention.In its report, the DTB calls on doctors to review all their cases in which aspirin has been prescribed as an anti-heart disease measure.Aspirin is frequently prescribed to patients with histories of heart diseases in order to stop future strokes or heart attacks. This is clearly a reactive measure - one that has been both going on for a long time and is known to be beneficial. What the report is saying, though, is that proactive aspirin prescription - issue of the drug pending the possibility of cardiovascular complications - needs to stop.
Aspirin: Heart Disease Prevention
The number of people in the UK who are being prescribed aspirin as a means of future heart disease prevention is thought to be in the thousands.
Over a four-year period beginning in 2005, a number of guidelines were issued that said aspirin should be used as a preventative measure in patients with no previous, evident heart problems, the Bulletin states. Among the patients groups covered were middle-aged-to-elderly Type 2 diabetics and people suffering from elevated blood pressure.
Aspirin: Gastrointestinal Bleeding:-
More recently, however, a study was published on six assessments that had taken place, and in which 95,000 patients were involved in all. This study -according to the Bulletin - drew attention to the risk of gastrointestinal bleeding episodes taking place within people who had taken aspirin. The same study also suggested that the link between the drug and death rates was fragile."Current evidence for primary prevention suggests the benefits and harms of aspirin in this setting may be more finely balanced than previously thought, even in individuals estimated to be at high risk of experiencing cardiovascular events, including those with diabetes or elevated blood pressure", the Bulletin's editor, Dr Ike Ikeanacho, explained.The new study has the backing of the Royal College of GPs. "Given the evidence, the DTB's statement on aspirin prescription is a sensible one", college chairman Professor Steve Field stated, adding that it would "...support their call for existing guidelines on aspirin prescription to be amended, and for a review of patients currently taking aspirin for prevention."Aspirin (USAN), also known as acetylsalicylic acid (pronounced /əˌsɛtɪlsælɪˌsɪlɪk ˈæsɪd/, abbreviated ASA), is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damage of the walls within blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk for developing blood clots.[1] It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue.The main undesirable side effects of aspirin are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses. In children and adolescents, aspirin is no longer used to control flu-like symptoms or the symptoms of chickenpox or other viral illnesses, because of the risk of Reye's syndrome.Aspirin was the first discovered member of the class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs), not all of which are salicylates, although they all have similar effects and most have inhibition of the enzyme cyclooxygenase as their mechanism of action. Today, aspirin is one of the most widely used medications in the world, with an estimated 40,000 tonnes of it being consumed each year. In countries where Aspirin is a registered trademark owned by Bayer, the generic term is acetylsalicylic acid (ASA).
Adverse effects Gastrointestinal:-
Aspirin use has been shown to increase the risk of gastrointestinal bleeding. Although some enteric coated formulations of aspirin are advertised as being "gentle to the stomach", in one study enteric coating did not seem to reduce this risk. Combining aspirin with other NSAIDs has also been shown to further increase this risk. Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding.
Central effects:-
Large doses of salicylate, a metabolite of aspirin, have been proposed to cause tinnitus, based on the experiments in rats, via the action on arachidonic acid and NMDA receptors cascade.
Other effects:-
Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, thirty patients were observed after their various surgeries. Twenty of the thirty patients had to have an additional unplanned operation because of postoperative bleeding. This diffuse bleeding was associated with aspirin alone or in combination with another NSAID in 19 out of the 20 who had to have another operation owing to bleeding after their operation. The average recovery time for the second operation was 11 days.Aspirin can induce angioedema in some people. In one study, angioedema appeared 1–6 hours after ingesting aspirin in some of the patients participating in the study. However, when the aspirin was taken alone it did not cause angioedema in these patients; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared.Aspirin causes an increased risk of cerebral microbleeds that is the appearance on MRI scans of 5–10 mm or smaller hypointense (dark holes) patches.Such cerebral microbleeds are important since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease and Alzheimers Disease.
Health researchers warned that Aspirin Can Cause Internal Bleeding ,so patients of Gastrointestinal Bleedings , and and suffering in Dengue Fever may be avoided to use it .Taking aspirin to protect against having a stroke or a heart attack where there is no visible evidence of heart problems should be avoided, according to new medical research published by the DTB (Drugs and Therapeutics Bulletin). Aspirin, it says, is capable of inducing significant internal, gastrointestinal bleeding, and there is no concrete link between it and heart disease death prevention.In its report, the DTB calls on doctors to review all their cases in which aspirin has been prescribed as an anti-heart disease measure.Aspirin is frequently prescribed to patients with histories of heart diseases in order to stop future strokes or heart attacks. This is clearly a reactive measure - one that has been both going on for a long time and is known to be beneficial. What the report is saying, though, is that proactive aspirin prescription - issue of the drug pending the possibility of cardiovascular complications - needs to stop.
Aspirin: Heart Disease Prevention
The number of people in the UK who are being prescribed aspirin as a means of future heart disease prevention is thought to be in the thousands.
Over a four-year period beginning in 2005, a number of guidelines were issued that said aspirin should be used as a preventative measure in patients with no previous, evident heart problems, the Bulletin states. Among the patients groups covered were middle-aged-to-elderly Type 2 diabetics and people suffering from elevated blood pressure.
Aspirin: Gastrointestinal Bleeding:-
More recently, however, a study was published on six assessments that had taken place, and in which 95,000 patients were involved in all. This study -according to the Bulletin - drew attention to the risk of gastrointestinal bleeding episodes taking place within people who had taken aspirin. The same study also suggested that the link between the drug and death rates was fragile."Current evidence for primary prevention suggests the benefits and harms of aspirin in this setting may be more finely balanced than previously thought, even in individuals estimated to be at high risk of experiencing cardiovascular events, including those with diabetes or elevated blood pressure", the Bulletin's editor, Dr Ike Ikeanacho, explained.The new study has the backing of the Royal College of GPs. "Given the evidence, the DTB's statement on aspirin prescription is a sensible one", college chairman Professor Steve Field stated, adding that it would "...support their call for existing guidelines on aspirin prescription to be amended, and for a review of patients currently taking aspirin for prevention."Aspirin (USAN), also known as acetylsalicylic acid (pronounced /əˌsɛtɪlsælɪˌsɪlɪk ˈæsɪd/, abbreviated ASA), is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.Aspirin also has an antiplatelet effect by inhibiting the production of thromboxane, which under normal circumstances binds platelet molecules together to create a patch over damage of the walls within blood vessels. Because the platelet patch can become too large and also block blood flow, locally and downstream, aspirin is also used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in people at high risk for developing blood clots.[1] It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue.The main undesirable side effects of aspirin are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses. In children and adolescents, aspirin is no longer used to control flu-like symptoms or the symptoms of chickenpox or other viral illnesses, because of the risk of Reye's syndrome.Aspirin was the first discovered member of the class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs), not all of which are salicylates, although they all have similar effects and most have inhibition of the enzyme cyclooxygenase as their mechanism of action. Today, aspirin is one of the most widely used medications in the world, with an estimated 40,000 tonnes of it being consumed each year. In countries where Aspirin is a registered trademark owned by Bayer, the generic term is acetylsalicylic acid (ASA).
Adverse effects Gastrointestinal:-
Aspirin use has been shown to increase the risk of gastrointestinal bleeding. Although some enteric coated formulations of aspirin are advertised as being "gentle to the stomach", in one study enteric coating did not seem to reduce this risk. Combining aspirin with other NSAIDs has also been shown to further increase this risk. Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding.
Central effects:-
Large doses of salicylate, a metabolite of aspirin, have been proposed to cause tinnitus, based on the experiments in rats, via the action on arachidonic acid and NMDA receptors cascade.
Other effects:-
Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, thirty patients were observed after their various surgeries. Twenty of the thirty patients had to have an additional unplanned operation because of postoperative bleeding. This diffuse bleeding was associated with aspirin alone or in combination with another NSAID in 19 out of the 20 who had to have another operation owing to bleeding after their operation. The average recovery time for the second operation was 11 days.Aspirin can induce angioedema in some people. In one study, angioedema appeared 1–6 hours after ingesting aspirin in some of the patients participating in the study. However, when the aspirin was taken alone it did not cause angioedema in these patients; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared.Aspirin causes an increased risk of cerebral microbleeds that is the appearance on MRI scans of 5–10 mm or smaller hypointense (dark holes) patches.Such cerebral microbleeds are important since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease and Alzheimers Disease.
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